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Replies to post #22926 on Rock Creek Pharmaceuticals Inc. (fka RCPIQ)
leifsmith
05/21/15 8:42 AM
#22927 RE: idcc2006 #22926
Icariin has been shown to protect DNA, nerve cells, and stem cells against free radical-induced damage in vitro.48-49, 51 Like resveratrol and curcumin, icariin appears to exert its potent anti-inflammatory effects via inhibition of NF-KappaB.50 In recent studies, icariin significantly decreased lung inflammation in mice by inhibiting a number of inflammatory compounds in mice such as tumor necrosis factor alpha (TNF-alpha), interleukin-6 (IL-6), cycloxygenase-2 (COX-2), prostaglandin E2 (PGE(2)), nitric oxide (NO) as well as NF-kappaB activation.50,52 In an in vitro study icariin partially reversed markers of inflammation and inflammation-induced joint degradation in cartilage cells from mice.4