I don't believe there is any need to approach Frost these two have been dancing for years now from what I can see. I would not mind having a chance encounter with Frost myself just to see what I might get from him off the cuff. Been here way longer than I planned on ,but aside from that no one ever said this one was going to be a walk in the park. PS: still not ruling out Pfizer although Shire appears far more viable at the moment.