The CTO was issued by the Province of British Columbia because Sarissa had not filed any information in this Canadian Province, and unfortunately at that time, since Merle ( representing IR for Sarissa was physically located in British Columbia ) Unlike the U.S. the Canadians have individual Province Regulators. It should also be noted that the ( OSC ) Ontario Securities Commission never bothered issuing a CTO. Since Merle has been replaced ( about a year ago now ) the British Columbia CTO is due for removal at any rate on this minor technicality. Generally speaking the Province Regulatory Agencies have been a toothless tea and crumpet party issuing their bureaucratic garbage for years......but then....I assume you already knew that.