The MRK trial in question will have all or almost all of its patients from outside the US. Now that Harvoni and V-Pak are widely available in the US, it would be nearly impossible to recruit US patients into a trial where half of them got Sovaldi + PEG/riba.
At the least, the emergence of this new drug suggests that MRK’s other drugs—including the nuke from IDIX—do not comprise a satisfactory pan-genotypic regimen.