Replies to post #90037 on Innovation Pharmaceuticals Inc (IPIX)

[edge]

It's pointless unless trials are conducted as of yesterday with patents expiring in 2020................Don't care how good it is.

[rr50]

I'm trying to grasp the significance of your post: Polymedix scientists employed 60,000 HOURS of computer time on the only non-governmental supercomputer in the U.S. This computer was able to do SIX TRILLION calculations per second! Multiplying six trillion by the number of seconds X 60,000 hours = An incomprehensible number! The technology behind Brilacidin's platform is truly astonishing. In addition, safety and efficacy seem exceptionally positive through two phase II trials(ON HUMANS)! There is light at the end of our tunnel...perhaps a supernova!! Thank SLC for posting your research.

[Orion Nebula]

Slc - Thanks for the backstory. I was startled by the following statement and wonder if the wording was accurate or if it was a bit loose.

"PolyMedix says it identified its lead drug candidate in less than 18 months for less than $2 million. The company believes it can have its first antibiotic drug on the market in five to six years, for about $100 million. It has created 12 classes of antibiotics and selected several of them as candidates for human trials, Mr. Landekic said. "We've shown that they kill more than 80 different strains of bacteria. Actually, we haven't found any strain of bacteria that we haven't been able to kill with these compounds," Mr. Landekic said. The compounds have been effective on the biowarfare pathogens black plague, tularemia and 12 strains of anthrax, he said."

The implication of CTIX possessing 12 classes of antibiotics is, to put it simply, mind boggling as there have only been 2 new classes of antibiotics developed since 1962. Here is a list of antibiotic classes:

http://en.wikipedia.org/wiki/List_of_antibiotics

As a side note: Couldn't help but notice someone added Teixobactin at the end as an antibiotic candidate. I wish I knew how to add Brilacidin in that section as a new class candidate far ahead of Teixobactin. Who knows, maybe someone on the board knows how to edit Wikipedia.

Anyway, back to the quote - I think it is more likely the reference is to twelve new molecules and I am hesitant to believe each represents a new class. I do not know this for sure as the article says classes but it is a newspaper article, albeit the WSJ, which, while a good paper, lacks the rigor of an academic journal article. Also, when the polyheist occurred, there was mention of a discrete number of molecules (I seem to recall 18 or something like that) but this is the first I have seen reference to 12 classes.

All of which raises the question as to whether subsequent work eliminated many of them or, alternatively, are they hiding down there in the patents etc. and have the potential to surface as future viable drug candidates and additional classes with analogues. If they are there - well, I don't know quite what to say.