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bladerunner1717

01/14/15 12:42 PM

#186056 RE: DewDiligence #186052

re: Tobira

Dew, Dr. Fischer and Mr. Peetz seem to be serious fellows. What do you think about their science?


Tobira Therapeutics Appoints Chairman Laurent Fischer, MD, Chief Executive Officer and Christopher Peetz Chief Financial Officer
March 26, 2014 11:18 AM Eastern Daylight Time
SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Tobira Therapeutics, a clinical-stage biopharmaceutical company advancing cenicriviroc (CVC) in liver disease and HIV, announced today that Laurent Fischer, MD, Tobira’s Chairman of the Board, has been appointed Chief Executive Officer. Christopher Peetz has joined the company as Chief Financial Officer.

“I look forward to leading our team with a clear sense of strategy and purpose through the next stages of clinical development for cenicriviroc in liver fibrosis and as part of a fixed-dose combination treatment for HIV, as well as in executing against our financing and business development objectives.”

“Tobira has established an impressive foundation of data for the company’s novel dual chemokine inhibitor program in multiple high-value therapeutic areas. With cenicriviroc demonstrating potent anti-fibrotic effects in preclinical studies, we are poised to commence a proof-of-concept clinical study in liver disease. We are also pursuing non-dilutive strategies for advancing cenicriviroc in combination with 3TC into pivotal studies as a new HIV treatment backbone, having shown long-term anti-viral efficacy and tolerability in more than a hundred HIV patients treated for up to 48-weeks,” said Dr. Fischer. “I look forward to leading our team with a clear sense of strategy and purpose through the next stages of clinical development for cenicriviroc in liver fibrosis and as part of a fixed-dose combination treatment for HIV, as well as in executing against our financing and business development objectives.”

“Dr. Fischer brings significant depth of leadership experience in the development and commercialization of new medicines addressing HIV and liver disease. His past accomplishments at Jennerex, Ocera, DuPont-Merck and Roche provide him with an ideal background to lead the advancement of cenicriviroc and maximize the development opportunities for this promising therapeutic,” said Founder and Director Eckard Weber, MD, Partner, Domain Associates. “We also welcome Chris Peetz. His blend of financial and business acumen will greatly strengthen the Tobira management team.”

The appointments of Dr. Fischer and Mr. Peetz are effective immediately, following the resignations of Andrew Hindman as Chief Executive Officer and Carolyn Loewy as Chief Financial Officer.

Dr. Fischer brings more than 20 years of drug development and commercialization experience in the biopharmaceutical industry. Most recently, Dr. Fischer was Chairman and Chief Executive Officer of Jennerex, Inc., a private, clinical-stage biotherapeutics company focused on cancer immunotherapy for liver cancer and other tumors, which was acquired by SillaJen, Inc. Prior, as Founder and Chief Executive Officer of Ocera Therapeutics, Inc., he licensed and developed a first-in-class ammonia scavenger for the treatment of complications of cirrhosis. Dr. Fischer held senior management positions at leading pharmaceutical companies including DuPont-Merck, DuPont Pharmaceuticals, and Hoffmann-La Roche with a focus on the development and commercialization of oncology, virology and liver disease products. Among other achievements, Dr. Fischer was responsible for the launch of Sustiva® the first once-daily anti-HIV drug, now part of the triple-combination therapy Atripla® and involved in the launch of Invirase®, the first protease inhibitor approved for HIV. He joined Tobira's Board of Directors in April 2009 and was elected Chairman in 2010, and served on the boards of AIDS Healthcare Foundation for a decade. Dr. Fischer received his undergraduate degree from the University of Geneva and his medical degree from the Geneva Medical School, Switzerland.

Mr. Peetz joins Tobira from Jennerex, where he served as Vice President, Finance & Corporate Development. While there, Mr. Peetz led a $21 million private financing and the sale of the company to SillaJen for up to $150 million including milestones. Prior to Jennerex, Mr. Peetz held positions of increasing responsibility at Onyx Pharmaceuticals, Inc. (now Amgen), including oversight of financial planning and analysis, corporate strategy, product lifecycle management and commercial roles on Nexavar®, Stivarga® and Kyprolis®. While at Onyx, Mr. Peetz supported public financings of nearly $300 million. Prior to Onyx, Mr. Peetz provided merger and acquisition advisory services at LaSalle Corporate Finance, a part of ABN AMRO, and held positions at Abgenix, Inc. and Solazyme, Inc. Mr. Peetz received an MBA from Stanford Graduate School of Business and BSBA from Washington University in St. Louis.

About Tobira Therapeutics

Tobira Therapeutics is a clinical-stage biopharmaceutical company developing cenicriviroc (CVC), an oral potent dual inhibitor of chemokine receptors CCR2 and CCR5. Tobira is initiating a Phase 2 clinical trial of cenicriviroc for the treatment of Nonalcoholic Steatohepatitis (NASH), a leading cause of cirrhosis and liver transplant. The company has also completed a Phase 2b clinical trial of cenicriviroc in 143 HIV-infected subjects, and the compound is positioned for Phase 3 studies as a novel, once daily, fixed-dose cenicriviroc/lamivudine backbone as part of combination HIV therapy. Tobira is backed by a syndicate of leading life science investors including Domain Associates, Frazier Healthcare Ventures, Montreux Equity Partners, Novo Ventures and Canaan Partners. Learn more at www.TobiraTherapeutics.com.

Contacts
BCC Partners for Tobira Therapeutics:
Karen L. Bergman, 650-575-1509
kbergman@bccpartners.com
Michelle Corral, 415-794-8662
mcorral@bccpartners.com


Bladerunner

DewDiligence

01/14/15 3:59 PM

#186087 RE: DewDiligence #186052

RGDO addendum: The remade company, which is essentially Tobira Therapeutics plus some added cash and a public listing, could be an interesting one to watch in the NASH arena. However, I will wait for more details from SEC filings and from the conference call next week before thinking about buying.

RGDO’s big rise today (+17%) may well be justified insofar as the company had no future as a standalone entity and, absent a merger, the cash balance would have eventually dwindled to zero.

bladerunner1717

01/14/15 10:37 PM

#186113 RE: DewDiligence #186052

re: RGDO

Dew,

If one wanted to buy the merged company's stock, what would be the best time to get in? RGDO is trading at a buck a share now. What will be the market cap of the new entity?

Bladerunner

DewDiligence

01/20/15 8:47 AM

#186323 RE: DewDiligence #186052

(RGDO)—Tobira starts phase-1 combination study in NASH:

http://finance.yahoo.com/news/tobira-therapeutics-doses-first-subject-120000825.html

Tobira Therapeutics…announced today that it has dosed the first subject in a Phase 1 study to evaluate the pharmacokinetics and safety in healthy subjects of cenicriviroc (CVC) and the diabetes medication pioglitazone, both when administered alone and in combination. The study supports Tobira's larger clinical program of CVC in non-alcoholic steatohepatitis (NASH), a disease associated with multiple comorbidities, including diabetes.

This is not Tobira’s lead clinical trial, which is a phase-2b study of Cenicriviroc monotherapy in NASH (https://www.clinicaltrials.gov/ct2/show/NCT02217475 ).

p.s. The CC for the reverse merger of Tobira into RGDO just ended. It was very short.

DewDiligence

05/04/15 4:40 PM

#190848 RE: DewDiligence #186052

RGDO officially becomes TBRA following 1:9 reverse split and additional financing:

http://finance.yahoo.com/news/tobira-therapeutics-completes-financing-merger-203000094.html

Tobira Therapeutics, Inc…announced today the completion of its merger with Regado Biosciences, Inc. In conjunction with the closing of the merger, Tobira raised $40 million of common stock from a combination of new investors and all current Tobira institutional investors, including the previously announced $13 million in debt that converted to common stock in this closing.

…Together with approximately $33 million net cash on Regado's balance sheet, the combined company has approximately $70 million in cash to advance clinical development of first-in-class dual CCR2/CCR5 inhibitor cenicriviroc (CVC), which is being evaluated in the Phase 2b CENTAUR clinical trial for the treatment of patients with non-alcoholic steatohepatitis (NASH) and liver fibrosis.

In connection with the merger, Regado changed its name to Tobira Therapeutics, Inc. and effected a nine for one reverse stock split. The combined company will commence trading as of tomorrow, May 5, 2015 on The NASDAQ Global Market under the symbol "TBRA."