Replies to post #110868 on Amarantus Bioscience Holdings Inc (AMBS)

[joboggi]

Well, that is a pr, and while those things happen, they rarely happen. Now, the drug amantidine is effective but it is NOT a cure.

IOW, a NEW drug will have to go a LONG way before it will be better than Amantidine.

Remember folks with PD were taking amantidine because it is an antiviral drug and the doctors noticed that it helped the LID symptoms remarkably.

Cutting and pasting prs does not change the fact that amantidine is VERY easy to take. Extremely easy. Remarkably easy. It has very few side effects as a matter of fact.

Now, all drugs have side effects but amantidine causes them only so often.

Cutting and pasting facts will not change current medical practice. It is true that new compounds need to be found, but well, the general class of compounds that begets Eltoprazine make it VERY unlikely that Eltoprazine will be tolerated for long periods of time. The people who have gotten Eltoprazine to date did not get the compound for very long, and very few got the compound for LID. This compound comes from a VERY sedating class of compounds.

Now, in one study, Eltoprazine worked BETTER when they combined it with Amantidine, and if Eltoprazine IS approved one day for LID, it will probably be used in combination with Amantidine, as a matter of fact.

That said, in that scenario you will have to prove in THOUSANDS of people that Eltoprazine/Amantidine is better than Amantidine alone.

You will only know if that is the case after testing in THOUSANDS of people concurrently.

I would put the chance of success at about 5%.

NOTE, it is DEFINITELY worth studying, and so it will be studied, but the proposed IIB study more than likely is not powered ( with many fewer than 200 patients ) to tell much. The FDA may well have something to say about that, by the way. I would NOT be surprised to have the FDA say that the study needs to be THIS big, (insert number here )

So, bottom line, if you copy paste the side effects for ANY compound, you will come up with a startling long list. That does not actually mean that much. The miracle is that most compounds can be taken by most people, as a matter of fact. And in general, if that is not the case, almost always ( except in LID ) there is another compound around that can be taken.