Image that the biggest side effect seems to be tumor lysis syndrome that leads to cytokines release syndrome as the patient' body tries to breakdown and digest the cancerous tumor tissue that is dying too quickly for the bodies enzymes to digest and clear out. Image the complaint that that cancerous cells are dying too quickly. Image that this therapy can put a stage 4 patient in complete remission within a month or sooner.
"...The huge therapeutic benefits of CAR T-cells do not come without side effects. CD19 occurs on all B cells and so one inevitable effect is B-cell aplasia that requires the lymphocytes to be replaced. Another side effect is tumor lysis syndrome, a fever that occurs when a tumor is being broken down.
Patients also suffer from cytokine release syndrome, but that has been managed successfully by treatment with the rheumatoid arthritis drug Roactemra (tocilizumab, Roche AG)...."
"...Furthermore, CTL19 is “agnostic to the genome of the tumor cells” and can kill cells that are chemotherapy-resistant, June noted. It has been shown that engineered T cells can kill cells from solid tumors in vitro, and preparations for clinical trials are starting up. “It’s about five years behind where we are with leukemia,” June said...."
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