From day 9 onwards, however, the patient became anuric. Ultrasound of the kidneys showed enlarged organs with a hypersonic parenchyma and no hydronephrosis. We initiated a continuous haemodiafiltration (Fresenius CiCa Multifiltrate; Fresenius, Bad Homburg, Germany).
From day 9-14 the anti-Ebola-virus IgG titres increased drastically
On day 13—after the haemodynamic situation had already stabilised—we used a haemofiltration cartridge (Haemopurifier; Aethlon, San Diego, CA, USA) for 6·5 h upstream to the regular system. This cartridge is designed to bind viral glycoproteins by lectin affinity.
This difference of less than a factor of 3 is within the technical variability range of the RNA PCR assay for Ebola virus and cannot be judged as a notable decrease.Moreover, the use of the filter had no effect on the overall decay kinetics of plasma viraemia in the 4-day period surrounding its application.
Published December 18, 2014
Authors:
Timo Wolf
MD, Gerrit Kann
Prof Stephan Becker
MD, Christoph Stephan
MD, Hans-Reinhardt Brodt
MD, Philipp de Leuw
MD, Thomas Grünewald
MD, Thomas Vogl
MD, Prof Volkhard A J Kempf
MD, Prof Oliver T Keppler
MD, Prof Kai Zacharowski
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