Replies to post #182919 on Biotech Values

[biomaven0]

>>why they've chosen to enroll very advanced patients not those with an earlier stage of the disease

One advantage of the later stage patients is they do indeed have AD. The earlier stage patients are likely a mix of various dementias and frail elderly patients in overall decline.

Ran across a company recently that is running a new Phase III in APOE4 patients only based on a subgroup analysis of an earlier failed trial.

Peter

[masterlongevity]

#AD drugs

they are probably looking for a symptomatic effect, where it is easier to see improvement when patients have a lot of symptoms.

earlier stage is important for determining any impact on disease modification.


there is no such thing as a possibility for reversal. Once neurons die, they're not coming back.