i dont know if this is the ingredient which is making the product get held up by Japanese authorities but it makes sense based on the DD i have done. it is considered a drug due to the membrane interface and acting as a carrier agent across the membrane (which makes it so effective). it also is this mechanism that cause some to pause to debate whether or not that should be considered a natural event or induced event and where the debate starts.
from there - it goes to what level does it become intrusive or harmful and/or can impair other cognitive functions. the recovery shot contains 50mg of Picamilon.
from several sites in the US - recommended dosage is anywhere from 50-500mg. HJOE recommends no more than two shots per day which would be consistent with the 100mg. the dosage would depend on weight, general tolerance to medication, and potential interactions with other medications - mostly blood pressure/thinners.
my guess is the debate is whether this level can be considered a dietary supplement in Japan or if ANY level requires a prescription. i have not been able to find anything specific on how Japan classifies dosage or if any level is considered beyond a supplement. there is a lot of information on Gaba and its use/natural sources in Japan. this provides a direct path to the receptors that allow Gaba to be more effective.
one more item that provides a pretty good, succinct summary:
Picamilon is an amazingly powerful compound with antioxidant properties, which has been available for over 25 years. Its primary use has been to support normal structure and function during aging. According to the third party literature, Picamilan has been used for nutritional support in the following situations: 1) tiredness and irritability, 2) depression, 3) decreased energy, 4) misuse of alcohol, and 5) anxiety.
An important benefit of using Pickamilon is that it is not a sedative, which means you can use Pickamilon and still drive and operate machinery, unlike when using tranquilizers (Picamilan, however, is not a substitute for medications prescribed by your physician.)
Picamilon shows different results at different dosages. A: The lower dosage, 50mg 3 times a day will achieve a tranquilizing nutritional effect. B.Increasing the dosage to 100 mg 3 times a day will bring about the nutritional stimulation effect and increase endurance.
The effects of Picamilon are felt quickly, most people will notice an impact within an hour and the body usually retains Pickamilon for up to six hours. It crosses the blood brain barrier easily, which is why the results are normally experienced so rapidly.
Pickamilon is a cleverly combined combination of the nutrients GABA and NIACIN. This chemical bonding of the two means the manufacturing process is formidable. Picamilon is an excellent substitute for minaprine and pramiracetam.
When Picamilon is used at the highest level, (250-300 mg per day) studies prove it to be more stimulating than piracetam and to have a more pronounced effect than vinpocetine. Other studies have shown Pickamilon has the ability to support blood circulation, and blood supply to the brain, in a manner far superior to the results achieved with either Hydergine or Xanthinol Nicotinate.
Picamilon has an extremely low toxicity and has shown no carcinogenic properties. In summation, as a nutrient Picamilan is a stimulating tranquilizer and can produce results more quickly than other products like Hydergine, Piracetam and Vinpocetine.
Description: Picamilan was first synthesized from nutrients in 1970. It is a white crystalline power that is odorless, highly hygroscopic and readily soluble in water. It is a combination of niacin and GABA in the same molecule, which increases to potency of each component (n-nicotinoyl uniquely bonded to GABA - gamma aminobutyric acid).
Method of Action: Affects cerebral circulation and neural regulation in similar manner to gamma aminobutyric acid (GABA). Anti-edematous action of Picamilan is linked with a change in energy metabolism in neurologic tissue.
Suggested Intake
Normal dosage(.01 to .05 grams). Acts on cerebral circulation and neural regulation to support a natural tranquilizing effect, restore balance between sympathetic and parasympathetic nervous systems, reduce the emotional effects of life stress and inhibit anxiety and aggression. May also be helpful in the nutritional support of Premenstrual Syndrome and Migraine Headaches. In higher doses (80-160 mg/kg) has a reciprocal stimulation effect. Does not induce muscle relaxation, drowsiness or lethargy.
Dosage and Administration: Time course of accumulation of Picamilan in the brain correlates with its blood level. Effect In: Approximately 30 minutes.
Adverse Reactions: Picamilan produces no known allergenic, teratogenic, embryotoxic or carcinogenic effects..
Known Interactive Effects: Valerian Root may inhibit the breakdown of GABA thereby enhancing its activity in the brain. Ginseng may also potentiate the activity of GABA
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