Sucralose has been accepted by several national and international food safety regulatory bodies, including the FDA, Joint Food and Agriculture Organization / World Health Organization Expert Committee on Food Additives, the European Union's Scientific Committee on Food, Health Protection Branch of Health and Welfare Canada, and Food Standards Australia New Zealand. According to the Canadian Diabetes Association, the amount of sucralose that can be consumed over a person's lifetime without any adverse effects is 9 mg/d/kg of body weight.[22][23]
"In determining the safety of sucralose, the FDA reviewed data from more than 110 studies in humans and animals. Many of the studies were designed to identify possible toxic effects, including carcinogenic, reproductive, and neurological effects. No such effects were found, and FDA's approval is based on the finding that sucralose is safe for human consumption." For example, McNeil Nutritional LLC studies submitted as part of its U.S. FDA Food Additive Petition 7A3987 indicated that "in the 2-year rodent bioassays ... there was no evidence of carcinogenic activity for either sucralose or its hydrolysis products ..."[24]
The Center for Science in the Public Interest, downgraded sucralose from "Safe" to "Caution" in June 2013, citing a new study linking sucralose consumption with leukemia risk in rats.[25][26] However, they also write, "It [sucralose] appears to be the safest artificial sweetener, though no independent tests have been conducted". The original Italian study has been criticized of being poorly executed and reported
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