Dmitry Gabrilovich : Peregrine Pharmaceuticals KOL :
Well Nov 14th is much too long to wait for Dmitry Gabrilovich to continue his March on with spreading the word of how powerful MDSC's can be in relation to homeostasis and for thee that can control MDSC's, will force Big Pharma into collaboration after collaboration... after collaborations
Bavituximab and PS Targeting looks to be that force that controls MDSC's, which in turn... brings complete stabilization back to homeostasis
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Alexander Lesokhin ... maybe we have more believers out there, than just the night nurses of IHUB
I am an oncologist who specializes in treating patients with multiple myeloma and related disorders. I am interested in understanding how cancers such as multiple myeloma are able to evade the immune system. My research focuses on learning how some treatments reverse this process and on developing innovative ways to use the immune system to treat multiple myeloma.
The advent of many new treatments in the past ten years makes this a very exciting time for physicians taking care of patients with multiple myeloma. Our team of myeloma specialists and support staff offers the newest treatments through a broad range of clinical trials to advance the level of care and improve the chance of a good outcome for all of our patients.
Do I hear blood test anyone? Now tell me this, those within the Data Monitoring Committee watching over Peregrines SunRise trial... will they be interested in blood tests ? Will the DMC use "ALL" knowledge there is in its entirety to make decision, to not watch patients remain on Docetaxel, without Bavituximab... if they know that Bavituximab decreases those MDSC's and those MDSC's are a biomarker ??? Hell... we have flipped-PS as the global biomarker of all cancer cells and we have MDSC's coming into biomarker territory. No wonder why all the fuss here lately.
Jedd Wolchok talks about immunotherapy and the foundation work set by William Coley, he mentions James Allison and pay attention to how he did not mention MDSC's in this video and he talks much about Ipilimumab (Yervoy) but one year later after this video >> in Dec 2013 he is working with Alexander Lesokhin on a new blood test for cancer patients, measuring circulating MDSC's
I know this video is devoted much to Yervoy, but Peregrine now has a combo trial with Yervoy+Bavi and with all this new information regarding MDSC's, Jedd Wolchok must be impressed
enjoy the next days or weeks or whatever... all hell is about to break loose