Replies to post #191239 on Avid Bioservices Inc (CDMO)

[asmarterwookie]

Here ya go bio... The future of crops...http://food.nationalgeographic.com/?utm_source=NatGeocom&utm_medium=Email&utm_content=food_20140921&utm_campaign=Content

If half of what we think PS involved in becomes a reality...
WHOA NELLIE!!!!!

wook

[biopharm]

Mychorrhizal fungi exerts flipped PS : Part II

Hidden Partners: Mycorrhizal Fungi and Plants
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The general public does not often consider the possibility of fungi acting as invasive species and/or allowing invasive plant species to spread in a non-native area. From European colonization in the late 1500's and continuing today with massive ocean freighters and airplanes, humans have been the major vector for plant and fungal movements on a intercontinental scale. Ballast, agricultural and horticultural introductions, accidental releases, and contaminated shipping material have all contributed to the introduction of invasive species. Although these introductions can often have drastic and disastrous consequences, invasive mychorrhizal fungi often spread unnoticed, beneath the ground and out of sight.
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http://sciweb.nybg.org/science2/hcol/mycorrhizae6.asp.html

[biopharm]

International Congress on Mycorrhizae
Oct 15-17

Mycorrhizal Symbiosis a key factor for improving plant productivity and ecosystems restoration....

I forgot about some yellow stickies re: Mycorrhizae and flipped PS that exists on diseased plants..trees...etc

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Aug 27 Assoc. Professor Todd Reynolds
Microbiology, UT The Roles of Phosphatidylserine in Host-Pathogen Interactions in Candida Albicans Gladys Alexandre

https://bcmb.utk.edu/news/seminar-series/past-seminars/

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Screen for phosphatidylserine synthase inhibitors: antifungals &lipid probes
Reynolds, Todd B.
University of Tennessee Knoxville, Knoxville, TN, United States

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NIH 2015
R01 AI Screen for phosphatidylserine synthase inhibitors: antifungals &lipid probes
Reynolds, Todd B. / University of Tennessee Knoxville $393,411

NIH 2014
R01 AI Screen for phosphatidylserine synthase inhibitors: antifungals &lipid probes
Reynolds, Todd B. / University of Tennessee Knoxville $353,781

NIH 2013
R01 AI Screen for phosphatidylserine synthase inhibitors: antifungals &lipid probes
Reynolds, Todd B. / University of Tennessee Knoxville $380,721

http://grantome.com/grant/NIH/R01-AI105690-03

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Masking of ß(1-3)-glucan in the cell wall of Candida albicans from detection by innate immune cells depends on phosphatidylserine.

Davis SE 1,
Hopke A 2,
Minkin SC Jr 3,
Montedonico AE 1,
Wheeler RT 2,
Reynolds TB 4.

Author information

1Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
2Department of Molecular and Biomedical Sciences, University of Maine, Orono, Maine, USA.
3Advanced Microscopy and Imaging Center, University of Tennessee, Knoxville, Tennessee, USA.
4Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA [e-mail].

Abstract

The virulence of Candida albicans in a mouse model of invasive candidiasis is dependent on the phospholipids phosphatidylserine (PS) and phosphatidylethanolamine (PE). Disruption of the PS synthase gene CHO1 (i.e., cho1?/?) eliminates PS and blocks the de novo pathway for PE biosynthesis. In addition, the cho1?/? mutant's ability to cause invasive disease is severely compromised. The cho1?/? mutant also exhibits cell wall defects, and in this study, it was determined that loss of PS results in decreased masking of cell wall ß(1-3)-glucan from the immune system. In wild-type C. albicans, the outer mannan layer of the wall masks the inner layer of ß(1-3)-glucan from exposure and detection by innate immune effector molecules like the C-type signaling lectin Dectin-1, which is found on macrophages, neutrophils, and dendritic cells. The cho1?/? mutant exhibits increases in exposure of ß(1-3)-glucan, which leads to greater binding by Dectin-1 in both yeast and hyphal forms. The unmasking of ß(1-3)-glucan also results in increased elicitation of TNF-a from macrophages in a Dectin-1-dependent manner. The role of phospholipids in fungal pathogenesis is an emerging field, and this is the first study showing that loss of PS in C. albicans results in decreased masking of ß(1-3)-glucan, which may contribute to our understanding of fungus-host interactions.

http://www.ncbi.nlm.nih.gov/pubmed/25114110