MULTICELL TECHNOLOGIES PUBLISHED PATENT: US PATENT 8,809,290
United States Patent 8,809,290 Assignee: Multicell Immunotherapeutics, Inc. (Woonsocket, RI) Bot, et al. August 19, 2014
Methods and compositions to generate and control the effector profile of T cells by simultaneous loading and activation of selected subsets of antigen presenting cells
Abstract
The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Tc1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-.gamma., IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process.
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