Oye! So here we go around this big Ole' circle jerk again,.....
I understand the concern expressed by Zinc and others,.... but it is largely unreasonable concern in that IF a significant problem was being introduced in an infected mammal by introducing a temporary overdose of the 'lock' mimic attached to a viruscide.
IF there were significant problems in (for example) introducing an overdose of a sialic acid mimic (sialic acid is the usual target or 'lock' on a cell surface) for the HA protein (= hemagglutinin as the Key in this example) in Flucide - they would already have been seen in the test animals.
Might there be some more subtle problem that has been overlooked so far? Sure - but we have no data suggesting that it is to this point.
No obvious toxic side effects have been seen in those animal models at what are believed to be clinically relevant doses of injectable or oral flucide. Similar non-toxic results have been observed in the animal systems and viruscide combinations that have been put forward so far.
Yes - those studies DO need to be followed up upon in formal TOX testing and in determining what a toxic dose actually may be - AND they need to be confirmed in populations of Humans,..... but there is no reason to expect that "suddenly" the molecules will prove to be toxic just because we are not running the chemistry in human Vs. mouse circulatory systems.
What functions do the sialic acid-rich glycoproteins normally have? They normally are found on human and other mammalian cell membrane surfaces and have a couple of basic functions. The primary one of these functions appears to be maintaining water balance at the surface of cells due to their slight negative charge attracting polar water molecules. So - in their primary function on a cell surface they don't really bind to ANY particular nutrient. So there is nothing really being depleted in the system (rich in water) in a bloodstream by adding a Nanovirucide.
As a secondary function (or of secondary importance) Sialic acid-rich glycoproteins are involved in binding to another set of protiens called Selectins. Selectins are a set of cell adhesion molecules - but themselves are also not limiting.
So - the worry in this case is overblown.
And even IF there is a real problem - it will become evident as TOX testing goes forward.
MUCH ADO ABOUT what is likely NOTHING here,.... again.
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