GJH, if I may.... I'm trying to pin down exactly what group, if any... that "hyperspectral microscope" falls in that you mentioned would be required to show the "real-time live cellular changes" taking place prior/during/post any form of PS Targeting drug being given:
Would any of these below fall into that category...> my guess is no.
By using molecular, biochemical and electron microscopic approaches - and - With a combination of flow cytometry, confocal live-cell imaging and electron microscopy
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These lipids – known as phosphatidylserine (PS) — are normally present on the inner side of the cellular membrane but can be exposed to the outer side upon viral infection. When the TIM-family proteins come in contact with PS, the viral particle becomes attached to the host cell, keeping the particle from being released from the cell. Because TIM-family proteins and PS are present on the surface of the cell and the viral particle, the viral particles get stuck to one another, forming a network of viral particles that accumulate on the surface of the host cell, rather than being released to infect other cells.
By using molecular, biochemical and electron microscopic approaches, the researchers observed the TIM and PS interactions in human cells. The next step is for the researchers to study the biological significance of TIM-family proteins in animals and patients and to determine the fate of the infected cell once it accumulates a buildup of viral particles.
With a combination of flow cytometry, confocal live-cell imaging and electron microscopy we demonstrate that the PS-immunoliposomes presented here are able to elicit efficient HIV-VLPs phagocytosis by macrophages and might represent a new nanotechnological approach to enhance HIV-1 antigen presentation and reduce the ongoing inflammation processes.
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