Details of Nuvilex's pre-clinical trials with TD2:
I don't know how many of those drugs Dr Von Hoff has worked with before but Albumin bound paclitaxel (nab-paclitaxel, Abraxane®)and Gemcitabine (Gemzar®)do stand out to me on that list.
I believe that combo is the Gold Standard now for pancreatic cancer. So, although we are testing ovarian cancer right now, it appears the combo of drugs would also work for pancreatic cancer. Nice...
"When the tumors have seeded in the abdomen, the mice will be randomized into four groups. One group of mice will be treated with Nuvilex's pancreatic cancer treatment consisting of the combination of Cell-in-a-Box(R) encapsulated live cells and the cancer prodrug ifosfamide (the encapsulated cells express an enzyme, CYP2B1, which converts ifosfamide into its cancer-killing form). A second group of mice will be treated with a drug normally used to treat ovarian cancer, and a third group will be administered that drug along with Nuvilex's Cell-in-a-Box(R) encapsulated live cells and ifosfamide combination. The remaining mice will serve as the "control" group for comparison purposes. The mice will be followed until humane endpoints have been reached. The time for this to occur for the treated mice will be compared to that for the control group of mice."
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