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biotech_researcher

08/11/14 6:52 AM

#52608 RE: Sikmarson #52607

Silkmarson, excellent find! KRAS would be huge. And, this is still Pona...

Jesspro

08/11/14 7:00 AM

#52609 RE: Sikmarson #52607

Very interesting assay. While nobody knows what the new molecule is yet, it could be a derivation from ponatinib. If that is the case, what has been inferred to in this assay that ponatinib can be used as a starting scafold for a drug to destabilize KRAS oncoprotein, it "could" be the highly awaited next molecule, maybe not. But it is a very tantalizing possibility...jmo.