Replies to post #95631 on NanoViricides Inc. (NNVC)

[BonelessCat]

I need to chime in here before this gets out of hand. EbolaCide was very effective in vitro but only slightly effective in vivo. This has to do with the problem of protein shedding where each Ebola virus surrounds itself in a cloud of decoys that defeat immune responses which means as a mimetic the EbolaCide particle must also penetrate the cloud.

Diwan developed a strategy and reengineered Ebolicide to penetrate the cloud, but in the meantime the contract for development went to other biopharmas, which later failed. The current most promising treatment is MB-003 produced by Mapp Biopharma.

The shedding is the primary reason that Ebola is able to work so successfully in defeating the immune system, but also the reason that at 60% fatality, outbreaks tend to burn themselves out.