Replies to post #180433 on Biotech Values

[mcbio]

ISIS has targeted TDP-43

Interesting. Thanks for the info. But, at over $3B market cap, that puts ISIS well into the mid-cap range for me. Still need that small-cap (<$500M market cap). ; )

[biomaven0]

>> targeted TDP-43

It's completely unclear right now (at least to me, and this is an area I follow pretty closely) what that would actually mean.

The most promising ALS work I know of is the recent publication out of Columbia showing that astrocytes from ALS patients produce an as-yet unidentified toxin that kills motor neurons via the necroptosis pathway.

(Necroptosis is a fairly recently discovered alternative death pathway to apoptosis).

Peter