Replies to post #102915 on Amarantus Bioscience Holdings Inc (AMBS)

[joboggi]

Calcium-dependent Protease As a Potential Therapeutic Target

Very interesting. Are you familiar with this compound?

the calpain protease is a link between the two Wolfram syndrome genes and death of neurons and ß cells.

For WS they found what is more than likely the holy grail. They know the genes involved, and now they have traced back to the enzyme that affects the symptoms of WS in the CNS and in the pancreas.

[joboggi]

What you found is a essentially a MANF replacement, or adjuvant. Given that

"the calpain protease is a link between the two Wolfram syndrome genes and death of neurons and ß cells"

They are implying that it is a direct link.

"We show that the Wolfram syndrome 2 gene product (WFS2) associates with and regulates calpain 2. Elevated activation of calpain 2, seen with WFS2 knockdown, correlates with increased death in neurons and ß cells; whereas suppression of calpain 2, seen with over-expression of WFS2, protects these cells from death."

Most certainly they are not talking about MANF.

Now, this is not necessarily a negative for MANF. It is just another compound that is in the mix during ER stress and cell death.

They need to figure out how it all fits together. I am sure that fumi has very specific ideas on how this may fit together, and so I would ask him.

In general when I post something that could be seen as a negative for MANF there is a negative reaction.

As best I can see, Fumi found the holy grail for the treatment of WS, and MANF may help with that.

We will have to see.