Replies to post #106499 on Elite Pharmaceuticals Inc (ELTP)

[Eltp]

It sounds like Elite technology to me

[steve9465]

The one thing that jumps out at me is it doesn't address intervienous use.

[Steges]

Senderos the manufacturing of ALO-02 is similar to Embeda's one-bead delivery platform tech which means right now you cannot assume the stability issues have been fixed. In addition, and of greater concern, would be the fact that in a clinical study of 400 pts, 60% of the pts discontinued taking the drug during a 12-month period, 20-30% due to the drugs side effects. Elite's delivery system is two-bead which is far less likely to have these types of stability issues.

[lasers]

senderos. Same old 1-bead story. Nothing new. ALO-02 is Oxycodone/Naltrexone and ALO-01 is Morphine/Naltrexone.

Pfizer makes their ADT with mechanical fusion of agonist and antagonist extruded strands in hot extruder. The problem is the same that Commercial manufacturing means OOM more heat and mechanical forces than in bench-scale or laboratory extruders. The agonist top strand is fused on to the bottom antagonist strand leading to potential wall damage to the antagonist sequestering polymer (SP). Damaged or fractured walls of the SP leads to premature Naltrexone leakage in the body's acid and alkaline fluids causing nausea, constipation and loss of agonist analgesic administering.

[dr_lowenstein]

wow!! great news thanks for sharing