Now, on top of that.... since we are entering the "immunotherapy" age of cancer treatment; Peregrine looks to have some very solid clinical evidence that there is a way via MDSC's/TAM's/Treg..etc to "scientifically" confirm that an optimal immune response has just taken place, occurring and should be a surrogate endpoint that leads to that primary endpoint of overall survival.
Ironically.... Big Pharma does not want this confirmation to take place, but its officially too late--- "cancer immunotherapy" is here to stay, just as PS Targeting will prove to be "required" if any treatment in order to provide that optimal immune response.
Big Pharma has some strong lobbyists.... but they will be up against quite a fight to go up against PS Targeting and back pocket "clear evidence of dose switching" leverage that is only part of some evidence that the FDA wants no part of opening those big can of worms.