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cabel

04/22/14 8:13 PM

#58785 RE: BonelessCat #58784

Even if MTD is at 220mg (Cohort-8 level) we will not get the Data Results for another year.

Thank goodness for B(ABSSI) and Prurisol, and hopefully B(OM).

When do you see Pruriosl Phase 2/3 starting,...?

Do you think they will wait for the B (ABSSSI) results before they get the Prurisol 2/3 going,...?

Same question for B(OM),.. do you think they will wait for B(ABSSSI) results first,...?

Thanks

noretreat

04/23/14 5:54 AM

#58791 RE: BonelessCat #58784

If the mtd were to be at least double the therapeutic dose, Kevetrin would enjoy a margin of safety not present in most other cancer treatments. This could give it a significant level of preference among oncologists.

As far as what those doses are...we have only the estimate by Dr. Menon that efficacy is likely in the 100-200 range. We don't know anything really beyond that. What about 300mg/m2? Does Kevetrin work even better at that level? I don't think anyone knows at this point. So let's find out. My point is that the higher the mtd, the better.