Avid Bioservices Inc (CDMO)

[entdoc]

geo, would you choose death or exile? Your choice. The company dies or it goes to India for human trials. Did we get to choose which cancer, which stage, which modality to combine with? Emphatically not. That was it. Enough money for one spin of the wheel. Before all that Bavi was supposed to be a double armed missile delivery system, but when preclinical (animal) trials showed indisputable immune-histological evidence of immunological activity, with massive movement of macrophages (garbage clean-up white blood cells) into Bavi-cancer interaction sites, we went that direction, with "naked" (unarmed) Bavi touted as an immunological stimulant, which it is. That puts us in a unique situation of indisputable safety and some moderate tumorcidal activity for upstream/macrophage/yada reasons bantered about ad nauseum here. Why do we still use chimeric (mouse-derived) parts to synthesize Bavi? Because it is more immunogenic... Bavi stimulates/alerts the immune system more than the fully humanized form of Bavi (now being made) which was a construct designed (by P Thorpe, UTSW) to carry a cytotoxic load directly to tumor...and that' where the guys that know are heading. Not toward a hopeless situation like Yervoy for melanoma. Note: we (treatment community) are heading toward more and more targeted therapy. Anti-PS has a definite role there.