Avid Bioservices Inc (CDMO)

[entdoc]

Couch, PPHM story incredible by any standard. You missed the decade of preclinical naysayers. And also the last gasp desperate grasp at straws to take clinical trials to India for human trials of Bavi + Chemo when PPHM finances were days from doom. It was a last gasp effort to get Bavi into humans at a bargain basement cost to the company in nearly-deads, and the results showed definite signs of anticancer activity...which has carried through with consistency through today. We knew THEN that Bavi + irradiation showed the greatest promise, but had no choice in what trials were open to it. Now we continue down that dead-end line of Bavi + irradiation for incurable disease...pancreas, melanoma, liver, etc. Hopefully PPHM can soon jump to another track after showing this staying power, and be used in less advanced disease to help prevent metastases and help clean up the dead cells and residual tumor after irradiation and surgery. Chemotherapy is going to soon be limited to targeted therapies taking small molecule cytotoxins specifically to tumor, and Bavi has that capability too. Remember, Bavi was first designed as a "double-fisted" monoclonal antibody capable of binding to cell wall phosphatidyserine (-PS) with one fist, and lobbing its payload carried on the other arm into tumor substance. We'll get there.