Zogenix (ZGNX)

[Ando Financing Firm]

The stock has reached a bottom. The medical field is now releasing the true information about the drug and worried citizens have contacted their politicians about the situation. I expect lawsuits to start being issues. Opana not being banned but able to be purchased is going to help Zogenix a ton. There was something last night about legalities being challenged of a state government being allowed to interfere with medical advice from a professional. A Governor banning a drug sounds like unauthorized practice of medicine to me.

The below letters were sent as discussions tailored off of this article that can be found on Seeking Alpha. http://seekingalpha.com/article/2107543-why-they-have-it-wrong-about-zogenix-and-you-would-be-right-to-buy#comment-31986633


This was copy/pasted with only the PII removed.

Even with my warning and sending Dr. Oz the correct information, the broadcast still chose to air this false, deceptive, and manipulative information to its viewers that resulted in Massachutts banning the drug. I advise that Dr. Oz go to great lengths to fix this error that has caused great injury to all of Zogenix's stakeholders. Please provide an update on Dr. Oz's plans to do so.

Thank you,
PII DELETED

________________________________________
Date: Wed, 26 Mar 2014 17:03:12 +0000
From: [e-mail]
To: PII DELETED
Subject: [Doctor Oz Support] Re: Support Request: The Dr. Oz TV Show -
##- Please type your reply above this line -##






Vicki
Mar 26 11:03
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PII DELETED
Mar 26 04:40
Good morning,
Thank you for the opportunity to write you to express my views on a topic that
is scheduled to be on your show today with Dr. Gupta. It was brought to my attention that Dr. Gupta
is going to be on your show to discuss opiod addiction and the epidemic that
has hit America. There is an opioid
epidemic and I love that your show is going to confront it with him on your
show today. Dr. Gupta is world-known and
I thought very highly of him until a few weeks ago. Unfortunately, his image has been tarnished
due to improper information he has begun to share with the public and he is
preparing to include your show. Zohydro,
that has been released this month. Dr.
Gupta is one of the various doctors and other media outlets that have spread
manipulating and plain false information; such as people were going to die the
day it was released and even called it as strong as heroin! Any doctor who gave
this information needs to either go to jail or lose all their certifications
because they are either being paid to provide false medical advice or fail to
have the intelligence to do so because all they needed to do was use a drug
comparison chart, called an equianalgesic chart. Instead of trying to ban it, the
Government should be suggesting its usage rather than its alternatives. Opana
and Oxycontin are much worse, even with the tamper-proof formulation. Plus, no
proper studies have been done to see all of the harm the formulation has on the
pain patients. Addicts will find a way to use, one way or another. What can be
prevented or minimized is the physical dependency. Hydrocodone has less
physical dependencies than the alternatives, especially Opana
PURPOSELY DELETED DUE TO PII
It is breaking my heart seeing all of these
lies that I see on TV and on the internet.
I just hate the lying and how people have sold their soul and it hurts
people who need it, especially since I don’t trust the tamper-resistant
formulation but Purdue will not address my concerns.
Zohydro ER (sometimes referred to as just Zohydro) is hydrocodone extended
release with no Acetaminophen/Tylenol, which studies have shown to severely
damage the liver. Hydrocodone is the most prescribed pain medication in the
world. There is, rightfully, concern for its potential to be abused and the
addictive nature of the drug, but I believe that the information presented
below will show why it was approved and should continue to be available through
a doctor's prescription. Additionally, I will include information on the owner
of the drug, Zogenix, and why I believe it is a strong buy at current prices.
Given the current situation, it is imperative to properly compare hydrocodone
(Zohydro ER) with oxycodone. Zohydro is less strong, making it easy for
physicians to manage dosage, and it carries lower risk of abuse. The argument
is pretty straightforward:

•
Zohydro is superior to oxycodone with respect to strength and abuse risk.

•
Oxycodone is already on the market (i.e., not banned/illegal).

•
Zohydro should be on the market too because it is easier to dose and safer

The articles
are extremely misleading because they leave out two critical elements: whether
or not Zohydro should be allowed on the market, and that it will kill its first
day on the market (it has been released since March 3, 2014, with zero deaths).
Click here
to read one of the articles. Unfortunately, this misleading information has
resulted in Ohio introducing a bill that would make it illegal to possess
or prescribe the drug. These articles have left out two critical elements.
There is no reference to users' physical dependency or how the strength of the
drug compares to other drugs out in the market. These are the most important
factors. Zohydro should be the last of the extended-release pain killers to be
illegal, as per the below information.
The proper way to compare drug strengths is through an equianalgesic
chart. I found it shocking to read so many articles, many of which
were commented on by doctors, that failed to use proper drug comparisons.
Oxycodone is almost twice as strong as hydrocodone, which means Zohydro is a
much weaker substitute for oxycodone (which is already on the market). The
anti-Zohydro groups need to pay attention and understand the significance of
this truth.
The fear that most have is based on addiction. What I haven't seen in any
articles posted about Zohydro is anything on its user dependency. Per Wikipedia, hydrocodone can be habit-forming, causing physical
and psychological dependence. Its abuse liability is similar to morphine and
less than oxycodone.
As per U.S. Pharmacist:

Oxycodone: Oxycodone is more potent and
causes fewer severe adverse effects (e.g., histamine release, pruritus, nausea)
than morphine. Oxycodone is metabolized by CYP2D6 to an active metabolite,
oxymorphone, which is now available in an oral formulation. However, unlike
codeine and hydrocodone, oxycodone is itself a potent analgesic. It is unknown
whether oxymorphone significantly contributes to the analgesic activity of
oxycodone. Patients with CYP2D6 deficiencies who do not respond well to codeine
or hydrocodone may achieve more pain relief by using oxycodone (the greater strength
of oxycodone increases abuse risk).
Oxycodone is available in combination with non-opioids or alone in immediate-
and sustained-release products. For the elderly, or for patients with renal
impairment, oxycodone requires less dosage adjustment and may be a safer
alternative to morphine.
Oxymorphone: Oxymorphone is approximately twice as potent as oxycodone. It
is more lipophilic than morphine, allowing for a faster onset of action. It is
available as an injection and as oral formulations: immediate-release (Opana)
and sustained-release (Opana ER). Because it has a longer half-life than
morphine, hydromorphone, and oxycodone, the immediate-release product may be
dosed at longer intervals (up to every six hours).

According to USA Today, Opana overtook oxycontin as the
painkiller most abused in the U.S. I would assume that the activists who are
protesting Zohydro would protest these two drugs before complaining about
Zohydro.
There have also been articles that only mention the largest Zohydro pill, 50
milligrams, and use its strength for all the comparisons. In my opinion, that
is blatant manipulation. There is no discussion on the lower dosages and how
they compare. Articles also compare it to heroin, yet these "experts"
fail to mention any credible research on that statement. It is difficult to
compare considering heroin comes in all types of different purity levels and is
cut with different drugs that change its strength.
As per the Opioid Analgesics site, using the U.S. Medication guide from
National Institutes of Health (NIH), Zohydro only had adverse reactions in =2%
of patients in placebo-controlled trials compared to in =5% or worse of the
other extended release medication besides Opana.
Zohydro is the extended version of our country's most prescribed pain
medication, hydrocodone (Vicodin). The person takes only 1 pill, which is
released to reduce pain over an extended amount of time (12 hours). The current
product requires the person to take a Vicodin every four hours, and the pill
currently includes acetaminophen. This is serious business because of how much
acetaminophen hurts a person's liver. The FDA has been developing regulations
to nearly banish Acetaminophen because of these devastating effects.
Now that you have the real information, please look into all of the parties who
knowingly spread false information. The two individuals I was surprised to see
discuss this issue the way that they did was Dr. Gupta and Senator Joe Manchin
(WV). I would like for Senator Manchin to clear his name after people on the
internet accuse him of using his status towards his own motives. According to
people on the internet, he has a connection to Mylan pharmaceuticals (which his
daughter is CEO) and trying to ban Zogenix's Zohydro ER (direct competitor of
daughters company). Supposedly, Mylan is the second highest contributor to
Senator Manchin's campaign (over $220,000,000.00). It is important to know that
Mylan produces more than one opiate painkiller, Hydrocodone (which is what
Zohydro is) and extended release Morphine pills stronger than Zohydro without
abuse deterrent technology, yet he is against Zohydro? That doesn't makes
sense....
America needs transparency and truth. I hope that you can give American's both.
Thank you,
PII DELETED




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