Cyclo Therapeutics Inc (CYTH)

[Lazarus]

Hydroxypropyl-beta-cyclodextrin and its combination with hydroxypropyl-methylcellulose increases aqueous solubility of delta9-tetrahydrocannabinol.

Jarho P1, Pate DW, Brenneisen R, Järvinen T.
Author information
Abstract

Delta9-tetrahydrocannabinol (THC) is the main psychoactive constituent of Cannabis sativa L. and its therapeutic effects are currently under intensive study. However, THC has a very low aqueous solubility (1-2 microg/mL), which restricts its use as a pharmaceutical. The present study demonstrates that THC forms a drug-cyclodextrin complex in an aqueous solution of hydroxypropyl-beta-cyclodextrin (HP-beta-CD), resulting in a thousand-fold increase in THC solubility. This improvement in solubility can be further increased by adding 0.1% hydroxypropylmethylcellulose to the HP-beta-CD solution. The present results suggest that the use of cyclodextrins might be a simple and useful method to overcome the poor water solubility of THC

I'm not a chemist but I can tell you that cannabis is heated to release the THC and when it is released it does not bind with water so butter is commonly used. Then the butter is put into cookies, brownies, whatever.

I assume that chemical nature of Cyclodextrins allow them to encapsulate the THC.... and according to that other article I posted, make it 1000 times more potent.

If you look at the information and the patents out there I think its pretty clear the marriage cannabis and cyclodextrins is going to happen. The question is WHO will do it. If CTD doesnt do it someone else will.