Avid Bioservices Inc (CDMO)

[entdoc]

It is difficult to OVERvalue the recent PPHM preclinical finding of total (100%) cure of lung cancer with Bavi+irradiation vs 17% with Bavi alone. We have become fixated here on Bavi+chemo when, in the real world of cancer treatment, chemotherapy is looked on with the greatest of disdain. There is a disconnect when one wants to eliminate a form of treatment which is currently a necessary evil, and then add something to it (Bavi) to make it more effective. True, we would like to eliminate irradiation therapy too (AND all cancers), but we have a shot at more kill zone specificity and less collateral damage with irradiation...and it appears that Bavi enormously helps clean up the mess with irradiation and probably increase sensitivity. The Bavi+irradiation study results of last week are enormous. Talking immunotherapy for prevention of primaries, prevention of recurrence, treatment of very small, or inhibition of metastases makes some sense. We're trying to get to a place where we can use focused irradiation and surgery (in whatever order) for primary and then salvage therapy, as needed. Chemotherapy at some point if you must. I know all oncologists do not agree with the above. That's how they make their living.