Amarantus Bioscience Holdings Inc (AMBS)

[MUKA1]

Dr. Urano's work is going to be a huge catalyst for MANF applications and associations with ophan ind. and the development of eye disease treaments. IMO.

UnivMiami Patent application for retinal disease treatment
“The receptors and signaling pathways of CDNF and MANF are unknown. While these two proteins have been considered to be potential treatments for Parkinson's disease, the inventor herein has considered them to be potential treatments for other neurodegenerative disorders, including retinal degenerative disorders, such as inherited retinal disorders, age-related macular degeneration, and glaucoma.”

http://patentscope.wipo.int/search/en/detail.jsf?docId=WO2012170918&recNum=2&maxRec=3&office=&prevFilter=&sortOption=Pub+Date+Desc&queryString=FP%3A%28Mesencephalic+Astrocyte+Derived+Neurotrophic+Factor%29&tab=PCTDescription


Dr. Urano's Blog:
1/20/2014
Testing if MANF (mesencephalic astrocyte-derived neurotrophic factor) can suppress the ER calcium leakage-mediated neuronal cell dysfunction in Wolfram iPSC-derived neural progenitor cells.

Sunday, March 9, 2014
Patient-based therapeutics part 7- Making eye cells
I am on my way to Japan to establish a collaboration with a major Japanese medical center on our Wolfram syndrome project. Why Japan? The reason is very simple. They have a technology to make eye cells from patient-derived induced pluripotent stem cells (iPS cells). If my research group can constantly make eye cells from Wolfram syndrome iPS cells, we can understand the mechanisms of optic atrophy in Wolfram syndrome and test the efficacy of our candidate drugs using these eye cells. This is also another opportunity to raise awareness of Wolfram syndrome.

As I repeatedly mentioned in my previous blogs, Wolfram is a weapon to combat diabetes and blindness. I believe that Wolfram is an accelerated form of diabetes and blindness. Many of us will experience beta cell death and death of eye cells later in our lives. A drug that can delay the progression of Wolfram may be helpful for us when we get old.

http://wolframsyndrome.blogspot.com/