However, I also believe the trial is underpowered. if we assume an OS delta of 2m, the trial is only 30% powered. At the extremes, 0m OS delta will give you 2.5% and 4m will give you 60%. So the truth is somewhere in between.
So I agree with people who say that the trial will likely fail but it is not doomed to fail as they say. This makes it a true gamble.
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