From a design standpoint, PRAN’s HD trial was rather like a typical phase-1b/2a PoC study—not a trial intended to inform an educated go/no-go decision for advancing to phase-3.
Among the various arguments promulgated by PRAN longs, the one I find most lacking in merit is that the HD program has conclusively been shown to be phase-3-ready.
“The efficient-market hypothesis may be the foremost piece of B.S. ever promulgated in any area of human knowledge!”
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