I havent read all the exchanges on this topic but it seems like the trenches are dug on the HD front and no one will be able to convince the other side through posts here.
To avoid a repeat of the same in AD, can you guys come up with what you would consider success AND failure in the AD trial. Something like, if xyz happens in the AD trial, I accept that PBT2 is active or placebo. Without that, we will see a repeat of HD.
This whole debacle in looking at the same trial results and seeing two different interpretations is the manifestation of a deeper issue in our society (what I called the lack of the Truth classes in the middle schools). Without that politicians will be able to convince public to go additional trillion dollar wars with selective evidence or companies will be able convince investors to waste billions in useless clinical trials.
So please, for your own sake, come up with your own primary end point BEFORE the AD trial results are announced.
