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Post# of 251942
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Re: Summer2762 post# 172375

Tuesday, 02/18/2014 1:45:10 PM

Tuesday, February 18, 2014 1:45:10 PM

Post# of 251942
Comparing my PR draft to the actual PR. I think I did a good job. :)

Theirs:

- Primary endpoints of safety and tolerability met.
- Secondary endpoint: Statistically significant improvement in a measure of executive function (cognition) in research participants administered 250mg PBT2 daily (p=0.042).
- PBT2 250mg was also associated with a favourable signal in functional capacity.
- Preliminary evidence suggests PBT2 250mg reduced atrophy of brain tissue in areas affected in Huntington disease, seen in a pilot imaging sub-study.
- Company plans to advance PBT2 to a confirmatory Phase 3 clinical trial.

Mine was (after filling the endpoints and p values):

- The primary outcome (safety and tolerability) met. [Near word by word match].

- Also, even though the trial was not powered to show efficacy, <executive function (cognition)> reached statistical significance (<p=0.042>) for <250mg arm>. [Near perfect match again].

- Furthermore, <functional capacity, reduced atrophy of brain tissue> were close to reaching statistical significance for <250mg> <insert the p values less than 0.2>. [I thought there would be 3 or 4 such endpoints. They PR'ed only 2 endpoints]

- We are very excited. These results show that Pbt2 is an amazing drug. [I seriously thought they'll say that they are taking PBT2 to phase 3, but I just laughed at the thought. So not a complete match but close.]



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