Fat versus Bone Marrow Stem Cell Counts: Now the Confusion Really Begins! As you can see from above, this issue is a lot more complex than it looks. In addition, it’s more confusing for doctors and patients alike when the proponents of fat stem cells claim that fat has more stem cells hence it must be better at everything. There are a few issues with that argument given what you learned above and adding in the following data:
1. Fat stem cell counts are usually wildly inflated by liposomes/micelles. These tiny bits of oil are often counted as cells when they are really just junk. There’s a nice paper on this issue here.
From that paper: “Intrigued by the high cell numbers (5 to 20 million cells/gram) reported by kit/device manufacturers such as MediVet-America (Lexington, KY), Intellicell Biosciences (New York, NY), and Adistem, Ltd. (Hong Kong) in adipose stem cell therapy compared to other methods (e.g., Chung,Vidal, and Yoshimura), INCELL staff conducted a research study to investigate the high apparent yield of stem cells. ” and…
“This study shows that incorrect counting of adipose derived SVF cells and the subset of regenerative stem cells can subsequently result in inaccurate dosing…The nature of adipose tissue itself with variability in dissociation by enzymatic digestion can all contribute to the outcomes. Fat tissue has a propensity to form acellular micelles and oils upon tissue disruption. Processing methods or reagents (e.g., Solution E or lecithins) can generate micelles that may be erroneously counted as cells.”
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