Avid Bioservices Inc (CDMO)

[Protector]

The early look-in will criteria have not been disclosed.

I believe it will be based on an number of enrolled patients + x weeks (so that the treatment of the last patients may work out).

How many? I would have to make a guess, so'll I'll say MAXIMUM 50% (300 patients). That is SPECULATION on my behave! I have nothing concrete to base that assumption on.

Given the extraordinary good PII results maybe the FDA granted 150. The look will not be event driven I think.

PPHM didn't add the 100 sites YET for the following reasons I think.

1) They had only about 50 from PII, so I suppose these business developers they recently hired are now working to increase that with new ones.

2) They probably started with 2 centres to dry-run the protocol to follow from enlisting the treatment centre up to and including some patients in each of these two centres.

3) When that went good they probably added the 4 next ones. I guess by now the first patients had their 5 weeks treatment.

4) When all that worked well (possible the CRO may have fine-tunes some stuff) they add some European centres.

5) Then they can add the rest that they already have. I think we'll have to look where they stand in MAR 2014.