Avid Bioservices Inc (CDMO)

[freethemice]

Betabodies are not mysterious. Here is the poster from the 2013 AACR meeting
http://www.peregrineinc.com/images/stories/pdfs/xianming_2013.pdf
Here is a diagram of a betabody. It is the Fc part of the mab fused to
domains I/V of beta2-GPI. So it is like a combination of PGN635 and beta2-GPI
into one entity. The Fc part binds to macrophages and DCs using their Fc-gamma
receptors, while domain V binds to PS. One of Thorpe's patents from 2006
describes an earlier version of a betabody.


There is no reason to expect a betabody to work any better than
the full mab attached to beta2-GPI, except for the fact that the half-life
in the blood is 5 times longer (~125 hrs vs. 25 hrs), and that could make
a big difference, but yet to be shown.



Here is Bavi/2aG4/1N11 binding to beta2-GPI