In actuality, in its current indication Iclusig is likely to capture an amount of the market consistent with that in the US.
Is Australia bound by the current U.S. label?
My opinion is that we will see much larger than expected percentages in the second line and a few in the front line both in the U.S. and Australia as we go forward. This off label use will slowly and consistently undermine all available therapies as we learn more on reducing CV events. We do already know that 20% of current Iclusig users are second line per the JPM presentation.
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