Avid Bioservices Inc (CDMO)

[entdoc]

exwan, you said, "The possibility of an immune response to a biologic agent is present in all biologics. Certainly this data is gathered in the early clinical trials. I doubt there is a showstopper there." Agreed, even though Cotara is mostly mouse, it isn't the type of cancercidal agent you plan to give repeatedly. Bavi, on the other hand, is something I would personally take weekly as a preventive/prophylaxis.
You said, "Also, I had suspected that GBM was chosen as the initial target to counter exactly this argument. The BBB works both directions." YES, I've said that for years. For those non-scientists here, the BBB Exwannabee is referring to is the blood brain barrier, a VERY import barrier to blood-borne pathogens and even some drugs. Cotara MAB is too large to be given IV and pass through the BBB (blood brain barrier), and into brain tissue, thus the microwave convection catheter delivering it directly into brain and into glioblastoma multiforme GBM malignant brain tumor.
You mentioned "TSA" issue, and I'm not sure what that abbreviation means. .