Avid Bioservices Inc (CDMO)

[entdoc]

stockweiser, Cotara IS as exciting as "naked-Bavituximab" (unarmed anti-PS MAB)because it is a killer of difficult, almost-impossible cancer cells found in the necrotic anaerobic miasma at the core of most large cancers which grow so fast they actually outstrip their blood supply. Those cells may become dormant, but not dead, and because of the anaerobic environment are difficult to kill. That is the attraction of I131 delivered (by whatever means)to the core of large (>1 inch) tumors which cannot be surgically resected. The I131 penetrates to the center and emits beta/gamma rays which kill for several mm.s in all directions. It is going to take big pharma capabilities to move Cotara to the treatment table though. It is possible that considerable work remains in reshaping the MAB, something I am hopeful will happen in China. However, absence of any word out of China on their "Cotara" trials is not a positive sign at this point 7? years after PPHM licensed it there. I could get very excited about a combination of Bavi and Cotara for hitting the surface of tumor,the blood supply, the immune system, and the core.