I think you misunderstood my point. What you describe is one definition of success. It is not the only definition. With 7 endpoints and 3 arms and no clear definition of success, how can this trial fail? If it cannot fail, how can it succeed?
Try to write a failure PR. You'll see that it will morph into one of two cases I wrote.
From investment point, investing for the HD trial seems to be a good idea just because the trial "cannot" fail. 21 nearly independent chances of statistical significance for the price of one is a good gamble. I think.
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