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Can-Fite BioPharma announces top-line results of Phase III

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mlkrborn   Monday, 12/30/13 10:10:21 AM
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Can-Fite BioPharma announces top-line results of Phase III Study with CF101 for dry eye syndrome; CF101 did not meet the primary efficacy endpoint (CANF) :

Co announced today that its subsidiary OphthaliX (OPLI) released results from a 24 week, placebo-controlled phase III study involving 237 patients with moderate-to-severe Dry Eye Syndrome who were treated with its licensed drug CF101, an A3 adenosine receptor agonist.
The patients were randomized to receive two oral doses of CF101 or a placebo, for a period of 24 weeks.
In the study, CF101 did not meet the primary efficacy endpoint of complete clearing of corneal staining, nor the secondary efficacy endpoints. Nonetheless, CF101 was found to be well tolerated.
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OphthaliX is also developing CF101 for the treatment of Glaucoma and Uveitis. The interim data from the ongoing phase II study in Glaucoma is expected to be released during 2014.

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