Pacific Biosciences of California Inc (PACB)

[Paulieme]

European Biotechnology News-- Exploiting the genome
04.12.2013 - PacBio, the UK’s Sanger Institute and Public Health England will analyse the genomes of 3,000 bacterial pathogens.

Using Pacific Biosciences' Single Molecule, Real-Time (SMRT) technology sequencing will be carried out at Europe’s largest sequencing hub, the Wellcome Trust’s Sanger Institute in Hinxton, UK, over the next three years. The finished genome sequences are to be stored in the GenBank database.

Most bacteria currently have no genome references and combining reference genomes with the wealth of historical and biological information existing for these strains will generate a data set of enormous value for clinical microbiology as well as basic research.

PacBio’s 3rd generation SMRT sequencing technology achieves the longest read lengths and highest consensus accuracy in the industry. Because the technology can directly detect base modifications, the epigenomes for bacteria can also be obtained with no additional data acquisition, providing unprecedented insight into the role of DNA methylation in bacterial pathogenicity.

Most recently, PacBio signed an exclusive agreement with global personalised healthcare major F. Hoffmann La-Roche to develop a SMRT sequencer suitable for clinical sequencing. The SMRT platform can uniquely read out a sequence without the error-prone PCR step required in other technologies.

eurobiotechnews.eu/tg

http://www.european-biotechnology-news.com/news/news/2013-04/exploiting-the-genome.html?utm_content=bufferbc6ee&utm_source=buffer&utm_medium=twitter&utm_campaign=Buffer