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Sunday, December 15, 2013 2:46:12 PM
In the end the only efficacy that will truly matter is stat sig efficacy from a properly powered p3 trial which leads to FDA approval... so it is technically correct to say that this level of efficacy has not been demonstrated... and in fact will not be for quite some time... however, it is equally appropriate to point out as you do that hints of efficacy at suboptimal doses are very encouraging... if increases in p21 biomarker activity track with a positive correlation to increased doses of K, that would be excellent... by JP Morgan that data should be avaiable through cohort 6... wonder if Leo will give it to us... fingers crossed...
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