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Re: A deleted message

Sunday, 12/15/2013 2:46:12 PM

Sunday, December 15, 2013 2:46:12 PM

Post# of 403092
There are hopeful signs of efficacy to be sure and the slide you post a link to is certainly a big one... you have mentioned before that quite a bit of data is now likely available at significantly higher doses... would love to see p21 data for these later cohorts at JP Morgan... not counting on it, but would love it...

In the end the only efficacy that will truly matter is stat sig efficacy from a properly powered p3 trial which leads to FDA approval... so it is technically correct to say that this level of efficacy has not been demonstrated... and in fact will not be for quite some time... however, it is equally appropriate to point out as you do that hints of efficacy at suboptimal doses are very encouraging... if increases in p21 biomarker activity track with a positive correlation to increased doses of K, that would be excellent... by JP Morgan that data should be avaiable through cohort 6... wonder if Leo will give it to us... fingers crossed...
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