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Re: changes_iv post# 77587

Friday, 12/13/2013 12:43:15 PM

Friday, December 13, 2013 12:43:15 PM

Post# of 146240
In Vivo Pharmacokinetic and Pharmacodynamic Studies for nanomedicines on cancer. How different are these nanomedicine studies from studies for nanoviricides in a host?

Pharmacokinetics/pharmacodynamics (PK/PD): Data collected at multiple timepoints after the administration of a nanomedicine in animal models allows for a complete pharmacokinetic and pharmacodynamic analysis of the nano agent in vivo. PK/PD assessments are performed using WinNonlin data management, a statistics, modeling, and visualization tool for PK data analysis. Parameters typically provided for a given nanomedicine include drug concentration over time, area under the curve (AUC), elimination half life, clearance, and time of maximum concentration.
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