Biotech Values

[genisi]

Progression of brain mets is a big worry in NSCLC with EGFR mutant or ALK positive but I don't see why it should happen while a patients is responding to Xalkori and before progression. Given that there is a time stress in your friend's case, I think that several months on Xalkori (average time to progression on Xalkori is about 9 months) could give the time to prepare for the next move and enter the next stage before progression would be better if possible. I would wait with ariad113 unless there are brain mets and clovis also a bit too early to be my first choice. All of course depending on mutation/s status.