Amarantus Bioscience Holdings Inc (AMBS)

[MUKA1]

These patents for applications of the MANF protein just keep popping up... I guess the pump and dump artists have them fooled too??

Patent published 8/21/2013 by Suzhou Institute of Tongji University Housing Jianmin

A recombinant fusion protein TAT-MANF and its application
. Using this method has been efficiently EGFP, ß- galactosidase , insulin and other proteins to the cells, or through the blood-brain barrier .


SUMMARY OF THE INVENTION
The present invention is to solve the technical problem of providing a recombinant fusion protein TAT-MANF and application of the recombinant fusion protein TAT-MANF across the cell membrane into the cell and play a good protective effect of nerve cells can slow Parkinson disease -related neuron disease , is a new type of medicine and good biotech drugs .
The present invention is a recombinant fusion protein TAT-MANF , is caused by human immunodeficiency virus trans-activator TAT protein transduction protein transduction domain of the fusion protein to form modified MANF , which sequence comprises the amino terminus of the TAT sequence and is located in a carboxyl group MANF end sequence . TAT sequence of SEQ ID NO: 1 shows the sequence or a variant or truncated sequences. The MANF sequence as SEQ ID NO: 2 shows the sequence or a variant or truncated sequences.
The present invention provides such a fusion protein by the TAT protein transduction domain and MANF composition , the present invention patent application is called TAT-MANF fusion protein fusion protein .
Recombinant TAT-MANF fusion protein contains two functional areas, each functional area functions as follows : TAT protein transduction domain is a basic amino acid -rich peptide fragments , the main function is to guide the fusion protein recombinant TAT-MANF penetrate the cell membrane . MANF main function is to promote the survival of dopaminergic neurons or rebuild the normal function of the dopaminergic nervous system , Parkinson's disease and dopamine as neuronal injury is closely related to the present invention, recombinant TAT-MANF fusion proteins can be used for the treatment of Parkinson's disease .



http://patentscope.wipo.int/search/en/detail.jsf?docId=CN92028786&recNum=1&office=&queryString=FP%3A%28manf%29&prevFilter=&sortOption=Pub+Date+Desc&maxRec=31

Yep, it's in Chinese...cut and paste into google translator...

Honest question though, this is an application of MANF or variation of, correct? Not a new protein?