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Re: akamaii post# 44279

Monday, 10/21/2013 7:02:36 PM

Monday, October 21, 2013 7:02:36 PM

Post# of 403061
Nice. Important not to forget that D is a wildcard drug that is also ready for Ph2 studies as soon as they can wrap their heads around what the source of the AE blood pressure drop was. It seems ripe for alternate dosing mechanics as a possible solution.

Interestingly the only competitor for D (a drug called protamine) has similar hypotension blood pressure effects if given too rapidly per the below.

"Too-rapid administration of protamine sulfate (protamine (protamines) s) can cause severe hypotensive and anaphylactoid-like reactions (see DOSAGE AND ADMINISTRATION). Facilities to treat shock should be available."
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