Ariad Pharmaceuticals Inc fka ARIA

[HiJames]

"Iclusig™ (ponatinib) is a kinase inhibitor indicated for the treatment of adult patients with chronic phase, accelerated phase, or blast phase chronic myeloid leukemia (CML) that is resistant or intolerant to prior TYROSINE kinase inhibitor therapy or Philadelphia chromosome positive acute lymphoblastic leukemia (Ph+ ALL) that is resistant or intolerant to prior TYROSINE kinase inhibitor therapy." http://www.iclusig.com/hcp/index.cfm

Tyrosine is amino acid , the possible codons are TAC , TAT. This is one of the BIGGEST variables in the composition of human genetics Take a look at the Human Genome ..... http://www.hgvs.org/mutnomen/codon.html